Genome-wide mapping of gene-microbe interactions in the murine lung microbiota based on quantitative microbial profiling.

ABSTRACT:

Background

Mammalian lungs comprise a complex microbial ecosystem that interacts with host physiology. Previous research demonstrates that the environment significantly contributes to bacterial community structure in the upper and lower respiratory tract. However, the influence of host genetics on the makeup of lung microbiota remains ambiguous, largely due to technical difficulties related to sampling, as well as challenges inherent to investigating low biomass communities. Thus, innovative approaches are warranted to clarify host-microbe interactions in the mammalian lung.

Results

Here, we aimed to characterize host genomic regions associated with lung bacterial traits in an advanced intercross mouse line (AIL). By performing quantitative microbial profiling (QMP) using th

SUBMITTER: Chung CJ 

PROVIDER: S-EPMC10234247 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature