The controversial effect of smoking and nicotine in SARS-CoV-2 infection.

ABSTRACT: The effects of nicotine and cigarette smoke in many diseases, notably COVID-19 infection, are being debated more frequently. The current basic data for COVID-19 is increasing and indicating the higher risk of COVID-19 infections in smokers due to the overexpression of corresponding host receptors to viral entry. However, current multi-national epidemiological reports indicate a lower incidence of COVID-19 disease in smokers. Current data indicates that smokers are more susceptible to some diseases and more protective of some other. Interestingly, nicotine is also reported to play a dual role, being both inflammatory and anti-inflammatory. In the present study, we tried to investigate the effect of pure nicotine on various cells involved in COVID-19 infection. We followed an organ-based sys

SUBMITTER: Salehi Z 

PROVIDER: S-EPMC10234254 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature