Incomplete erasure of histone marks during epigenetic reprogramming in medaka early development.

ABSTRACT: Epigenetic modifications undergo drastic erasure and reestablishment after fertilization. This reprogramming is required for proper embryonic development and cell differentiation. In mammals, some histone modifications are not completely reprogrammed and play critical roles in later development. In contrast, in nonmammalian vertebrates, most histone modifications are thought to be more intensively erased and reestablished by the stage of zygotic genome activation (ZGA). However, histone modifications that escape reprogramming in nonmammalian vertebrates and their potential functional roles remain unknown. Here, we quantitatively and comprehensively analyzed histone modification dynamics during epigenetic reprogramming in Japanese killifish, medaka (Oryzias latipes) embryos. Our data

SUBMITTER: Fukushima HS 

PROVIDER: S-EPMC10234297 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature