Motif conservation, stability, and host gene expression are the main drivers of snoRNA expression across vertebrates.

ABSTRACT: Small nucleolar RNAs (snoRNAs) are structured noncoding RNAs present in multiple copies within eukaryotic genomes. snoRNAs guide chemical modifications on their target RNA and regulate processes like ribosome assembly and splicing. Most human snoRNAs are embedded within host gene introns, the remainder being independently expressed from intergenic regions. We recently characterized the abundance of snoRNAs and their host gene across several healthy human tissues and found that the level of most snoRNAs does not correlate with that of their host gene, with the observation that snoRNAs embedded within the same host gene often differ drastically in abundance. To better understand the determinants of snoRNA expression, we trained machine learning models to predict whether snoRNAs are expressed

SUBMITTER: Fafard-Couture E 

PROVIDER: S-EPMC10234308 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature