Clinical correlates and prognostic implications of severe suicidal ideation in major depressive disorder.

ABSTRACT: Suicidal ideation (SI) is a risk factor for suicidal behaviour. To ascertain the clinical correlates and prognostic impact of severe SI, we analysed 249 outpatients with major depressive disorder (MDD) and suicidal thoughts included in the COmbining Medications to Enhance Depression outcome (CO-MED) trial. Patients with severe SI (36%) were younger at disease onset ( P  = 0.0033), more severely depressed ( P  = 0.0029), had more lifetime suicidal behaviour ( P  < 0.0001) and psychiatric comorbidities (panic disorder: P  = 0.0025; post-traumatic stress disorder: P  = 0.0216), and a history of childhood maltreatment (neglect: P  = 0.0054; emotional abuse: P  = 0.0230; physical abuse: P  = 0.0076; sexual abuse: P  = 0.0016) than those experiencing low-moderate SI. After controlling for depres

SUBMITTER: Olgiati P 

PROVIDER: S-EPMC10234328 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature