Body composition and risk of liver cancer: a population-based prospective cohort study on gender difference.

ABSTRACT:

Background

Obesity is a common and highly convincing risk factor for many cancers, including liver cancer. Sex disparities in the body composition and regulatory mechanisms involved in energy homeostasis may contribute to the difference in the incidence of cancer. However, evidence on the gender-specific association between body composition and liver cancer incidence is limited. We performed this study to investigate the linear and non-linear associations of body composition with liver cancer risk by gender.

Materials and methods

This prospective analysis included 4,75,659 participants free of cancer, based on the UK Biobank. We used Cox proportional hazard models to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for potential confounder

SUBMITTER: Pi S 

PROVIDER: S-EPMC10234331 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature