Dataset Information

Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent.

ABSTRACT:

Objectives

To determine how the intrinsic severity of successively dominant SARS-CoV-2 variants changed over the course of the pandemic.

Methods

A retrospective cohort analysis in the NHS Greater Glasgow and Clyde (NHS GGC) Health Board. All sequenced non-nosocomial adult COVID-19 cases in NHS GGC with relevant SARS-CoV-2 lineages (B.1.177/Alpha, Alpha/Delta, AY.4.2 Delta/non-AY.4.2 Delta, non-AY.4.2 Delta/Omicron, and BA.1 Omicron/BA.2 Omicron) during analysis periods were included. Outcome measures were hospital admission, ICU admission, or death within 28 days of positive COVID-19 test. We report the cumulative odds ratio; the ratio of the odds that an individual experiences a severity event of a given level vs all lower severity levels for the resident and the replacement variant after adjustment.

Results

After adjustment for covariates, the cumulative odds ratio was 1.51 (95% CI: 1.08-2.11) for Alpha versus B.1.177, 2.09 (95% CI: 1.42-3.08) for Delta versus Alpha, 0.99 (95% CI: 0.76-1.27) for AY.4.2 Delta versus non-AY.4.2 Delta, 0.49 (95% CI: 0.22-1.06) for Omicron versus non-AY.4.2 Delta, and 0.86 (95% CI: 0.68-1.09) for BA.2 Omicron versus BA.1 Omicron.

Conclusions

The direction of change in intrinsic severity between successively emerging SARS-CoV-2 variants was inconsistent, reminding us that the intrinsic severity of future SARS-CoV-2 variants remains uncertain.

SUBMITTER: Pascall DJ

PROVIDER: S-EPMC10234362 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Publications

Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent.

Pascall David J DJ Vink Elen E Blacow Rachel R Bulteel Naomi N Campbell Alasdair A Campbell Robyn R Clifford Sarah S Davis Chris C da Silva Filipe Ana A El Sakka Noha N Fjodorova Ludmila L Forrest Ruth R Goldstein Emily E Gunson Rory R Haughney John J Holden Matthew T G MTG Honour Patrick P Hughes Joseph J James Edward E Lewis Tim T MacLean Oscar O McHugh Martin M Mollett Guy G Nyberg Tommy T Onishi Yusuke Y Parcell Ben B Ray Surajit S Robertson David L DL Seaman Shaun R SR Shabaan Sharif S Shepherd James G JG Smollett Katherine K Templeton Kate K Wastnedge Elizabeth E Wilkie Craig C Williams Thomas T Thomson Emma C EC

The Journal of infection 20230601 2

<h4>Objectives</h4>To determine how the intrinsic severity of successively dominant SARS-CoV-2 variants changed over the course of the pandemic.<h4>Methods</h4>A retrospective cohort analysis in the NHS Greater Glasgow and Clyde (NHS GGC) Health Board. All sequenced non-nosocomial adult COVID-19 cases in NHS GGC with relevant SARS-CoV-2 lineages (B.1.177/Alpha, Alpha/Delta, AY.4.2 Delta/non-AY.4.2 Delta, non-AY.4.2 Delta/Omicron, and BA.1 Omicron/BA.2 Omicron) during analysis periods were includ ...[more]

PMID: 37270070

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Dataset Information

Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent.

Objectives

Methods

Results

Conclusions

Publications

Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent.

Similar Datasets

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