Social experience and pheromone receptor activity reprogram gene expression in sensory neurons.

ABSTRACT: Social experience and pheromone signaling in olfactory neurons affect neuronal responses and male courtship behaviors in Drosophila. We previously showed that social experience and pheromone signaling modulate chromatin around behavioral switch gene fruitless, which encodes a transcription factor necessary and sufficient for male sexual behaviors. Fruitless drives social experience-dependent modulation of courtship behaviors and physiological sensory neuron responses to pheromone; however, the molecular mechanisms underlying this modulation of neural responses remain less clear. To identify the molecular mechanisms driving social experience-dependent changes in neuronal responses, we performed RNA-seq from antennal samples of mutants in pheromone receptors and fruitless, as well as grouped

SUBMITTER: Deanhardt B 

PROVIDER: S-EPMC10234412 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature