Microbiota transfer following liver surgery involves microbial extracellular vesicle migration that affects liver immunity.

ABSTRACT:

Background

Short-term perioperative administration of probiotics was shown to alleviate postoperative complications and promote liver recovery among patients undergoing resection for liver malignancy. The mechanisms by which probiotic bacteria effectively influence the gut microbiome composition during the perioperative time are controversial. Here, we aim to elucidate the short-term direct biological effect of probiotic microbiota-derived vesicles on host liver cells during the perioperative period.

Methods

Probiotic-derived vesicles (pbMVs) were administered postoperatively. pbMVs were isolated and characterized from probiotics, mainly from the bacteria genus Lactobacillus, Bifidobacterium, and Lactococcus. Mice underwent bile duct ligation, sham laparotomy (SHAM), or 70%

SUBMITTER: Cohen SJ 

PROVIDER: S-EPMC10234462 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature