Comprehensive pan-cancer analysis of PTGES3 and its prognostic role in hepatocellular carcinoma.

ABSTRACT:

Introduction

PTGES3, also known as p23, is a molecule chaperone of Hsp90 that is involved in the pathogenesis of malignant tumors. Increasing studies have shown that PTGES3 plays a nonnegligible role in tumor development. However, analysis of PTGES3 in pan-cancer has not been performed yet.

Methods

We explored the role of PTGES3 in 33 types of tumors and depicted the potentialimmune-related pathways among them. Using multiple databases includingTCGA, LinkedOmics, GDSC, and TIMER, we made a comprehensive analysis to explore whether there was an interaction between PTGES3 and prognosis, DNA methylation, copy number variation (CNV), tumor mutational burden (TMB), microsatellite instability (MSI), and tumor immune microenvironment (TME).

Results

Our study revealed that PT

SUBMITTER: Wang H 

PROVIDER: S-EPMC10234500 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature