Impact of bisoprolol and amlodipine on cardiopulmonary responses and symptoms during exercise in patients with chronic obstructive pulmonary disease.

ABSTRACT:

Background

Patients with chronic obstructive pulmonary disease (COPD) often have exercise intolerance. The prevalence of hypertension in COPD patients ranges from 39-51%, and β-blockers and amlodipine are commonly used drugs for these patients.

Objectives

We aimed to study the impact of β-blockers and amlodipine on cardiopulmonary responses during exercise.

Methods

A total 81 patients with COPD were included and the patients underwent spirometry, cardiopulmonary exercise tests, and symptoms questionnaires.

Results

There were 14 patients who took bisoprolol and 67 patients who did not. Patients with COPD taking ß-blockers had lower blood oxygen concentration (SpO2) and more leg fatigue at peak exercise but similar exercise capacity as compared with patients not

SUBMITTER: Lan CC 

PROVIDER: S-EPMC10234532 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature