Population pharmacokinetic model of ivermectin in mass drug administration against lymphatic filariasis.

ABSTRACT:

Background

Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat diseases caused by filarial worms, such as onchocerciasis and lymphatic filariasis (LF). IVM is part of a triple-drug therapy used by the Mass Drug Administration (MDA) as a preventive strategy to eradicate LF in sub-Saharan Africa. The drug shows high variability in drug exposure in previous pharmacokinetic studies. This study aims to build a population pharmacokinetic (PopPK) model to identify and quantify the possible sources of the variability of IVM exposure after a single-oral dose in LF-infected subjects and healthy individuals.

Methodology / principal findings

In this analysis, 724 samples were collected from treatment-naïve Wuchereria bancrofti-infected (n = 32) and uninfected (n = 24) a

SUBMITTER: Alshehri A 

PROVIDER: S-EPMC10234547 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature