Molecular subtypes and tumor microenvironment infiltration signatures based on cuproptosis-related genes in colon cancer.

ABSTRACT:

Background

Colon cancer is one of the common cancers, and its prognosis remains to be improved. The role of cuproptosis as a newly discovered form of cell death in the development of colon cancer has not been determined.

Methods

Based on 983 colon cancer samples in the TCGA database and the GEO database, we performed a comprehensive genomic analysis to explore the molecular subtypes mediated by cuproptosis-related genes. Single-sample gene set enrichment analysis (ssGSEA) was utilized to quantify the relative abundance of each cell infiltrate in the TME. A risk score was established using least absolute shrinkage and selection operator regression (LASSO), and its predictive ability for colon cancer patients was verified to explore its guiding value for treatment.

Results<

SUBMITTER: Luo H 

PROVIDER: S-EPMC10234596 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature