The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate.

ABSTRACT: Genes associated with increased susceptibility to multiple sclerosis (MS) have been identified, but their functions are incompletely understood. One of these genes codes for the RNA helicase DExD/H-Box Polypeptide 39B (DDX39B), which shows genetic and functional epistasis with interleukin-7 receptor-α gene (IL7R) in MS-risk. Based on evolutionary and functional arguments, we postulated that DDX39B enhances immune tolerance thereby decreasing MS risk. Consistent with such a role we show that DDX39B controls the expression of many MS susceptibility genes and important immune-related genes. Among these we identified Forkhead Box P3 (FOXP3), which codes for the master transcriptional factor in CD4⁺/CD25⁺ T regulatory cells. DDX39B knockdown led to los

SUBMITTER: Hirano M 

PROVIDER: S-EPMC10234631 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature