Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2.

ABSTRACT: Acute lung injury and its severe form acute respiratory distress syndrome are lethal lung diseases. So far, effective therapy for the diseases is deficient and the prognosis is poor. Recently, it was found activating nuclear factor erythroid 2-related factor 2 could attenuate the injury including inflammation, oxidative stress, and apoptosis in those diseases. To discover novel therapy, we have evaluated safflor yellow A and explored the underlying mechanisms using Beas-2B cells injured by lipopolysaccharide. As a result, safflor yellow A could improve the viability of Beas-2B cells treated with lipopolysaccharide. Further investigations have revealed safflor yellow A suppressed oxidative stress induced by lipopolysaccharide via reducing reactive oxygen species and malondialdehyde, and ele

SUBMITTER: Chen LS 

PROVIDER: S-EPMC10234683 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature