Distinct skin microbiome community structures in congenital ichthyosis.

ABSTRACT:

Background

The ichthyoses are rare genetic keratinizing disorders that share the characteristics of an impaired epidermal barrier and increased risk of microbial infections. Although ichthyotic diseases share a T helper (Th) 17 cell immune signature, including increased expression of antimicrobial peptides, the skin microbiota of ichthyoses is virtually unexplored.

Objectives

To analyse the metagenome profile of skin microbiome for major congenital ichthyosis subtypes.

Methods

Body site-matched skin surface samples were collected from the scalp, upper arm and upper buttocks of 16 healthy control participants and 22 adult patients with congenital forms of ichthyosis for whole metagenomics sequencing analysis.

Results

Taxonomic profiling showed significant shifts

SUBMITTER: Tham KC 

PROVIDER: S-EPMC10234690 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature