3D-printed GelMA/CaSiO3 composite hydrogel scaffold for vascularized adipose tissue restoration

ABSTRACT: Abstract The increased number of mastectomies, combined with rising patient expectations for cosmetic and psychosocial outcomes, has necessitated the use of adipose tissue restoration techniques. However, the therapeutic effect of current clinical strategies is not satisfying due to the high demand of personalized customization and the timely vascularization in the process of adipose regeneration. Here, a composite hydrogel scaffold was prepared by three-dimensional (3D) printing technology, applying gelatin methacrylate anhydride (GelMA) as printing ink and calcium silicate (CS) bioceramic as an active ingredient for breast adipose tissue regeneration. The in vitro experiments showed that the composite hydrogel scaffolds could not only be customized with controllable architectures, but al

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PROVIDER: S-EPMC10234763 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature