Diffuse Intrinsic Pontine Glioma: From Diagnosis to Next-Generation Clinical Trials.

ABSTRACT:

Purpose of review

This review of diffuse intrinsic pontine glioma (DIPG) provides clinical background, a systematic approach to diagnosis and initial care, and synthesizes historical, modern, and future directions for treatment. We present evidence supporting neurosurgical biopsy, early palliative care involvement, limitation of glucocorticoid use, and the leveraging of preclinical DIPG models as a pipeline to next-generation clinical trials.

Recent findings

New molecular understanding of pediatric high-grade gliomas has led to the reclassification of DIPG as one member of a family of diffuse gliomas occurring in the midline of the central nervous system that exhibit pathognomonic mutations in genes encoding histone 3 (H3 K27M). DIPG remains a clinically relevant term, thoug

SUBMITTER: Vitanza NA 

PROVIDER: S-EPMC10234769 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature