Significance of cuproptosis-related lncRNA signature in LUAD prognosis and immunotherapy: A machine learning approach.

ABSTRACT:

Objective

Cuproptosis-related genes are closely related to lung adenocarcinoma (LUAD), which can be analyzed via the analysis of long noncoding RNA (lncRNA). To date, the clinical significance and function of cuproptosis-related lncRNAs are still not well elucidated. Further analysis of cuproptosis-related prognostic lncRNAs is of great significance for the treatment, diagnosis, and prognosis of LUAD.

Methods

In this study, a multiple machine learning (ML)-based computational approach was proposed for the identification of the cuproptosis-related lncRNAs signature (CRlncSig) via comprehensive analysis of cuproptosis, lncRNAs, and clinical characteristics. The proposed approach integrated multiple ML algorithms (least absolute shrinkage and selection operator regression analy

SUBMITTER: Yang L 

PROVIDER: S-EPMC10234775 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature