Circular RNA-mediated ceRNA network was identified in human lung adenocarcinoma by high-throughput sequencing.

ABSTRACT:

Objectives

Aberrantly expressed circular RNAs (circRNAs) have been detected in many types of tumors. Hence, they are currently investigated as candidate biomarkers for diagnostic and potential targets for therapy in cancers. The objective of this study was to assess the expression profile of circRNA in lung adenocarcinoma (LUAD).

Methods

This study included 14 pairs of postoperative lung adenocarcinoma specimens, including cancer tissues and matched adjacent tissues. Second-generation sequencing was applied to the specimens to determine the circRNA expression in them among the 5242 distinct circRNAs detected.

Results

We identified a total of 18 significantly dysregulated circRNAs in the LUAD tissues: upregulation in four and downregulation in 14. ROC (The receiver ope

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10234779 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature