Infection of neonatal mice with the murine norovirus strain WU23 is a robust model to study norovirus pathogenesis.

ABSTRACT: Noroviruses are the leading cause of severe childhood diarrhea and foodborne disease worldwide. While they are a major cause of disease in all age groups, infections in the very young can be quite severe, with annual estimates of 50,000-200,000 fatalities in children under 5 years old. In spite of the remarkable disease burden associated with norovirus infections, very little is known about the pathogenic mechanisms underlying norovirus diarrhea, principally because of the lack of tractable small animal models. The development of the murine norovirus (MNV) model nearly two decades ago has facilitated progress in understanding host-norovirus interactions and norovirus strain variability. However, MNV strains tested thus far either do not cause intestinal disease or were isolated from extrai

SUBMITTER: Peiper AM 

PROVIDER: S-EPMC10234811 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature