Comparison of two intraductal brush cytology devices for suspected malignant biliary strictures: randomized controlled trial.

ABSTRACT:

Background

Endoscopic retrograde cholangiopancreatography (ERCP) with biliary brush cytology is commonly used to diagnose malignant pancreatobiliary strictures. This trial compared the sensitivity of two intraductal brush cytology devices.

Methods

A randomized controlled trial in which consecutive patients with suspected malignant, extrahepatic biliary strictures were randomized (1:1) to a dense or conventional brush cytology device. Primary endpoint was sensitivity. Interim analysis was conducted after 50% of the patients completed follow-up. Results were interpreted by a data safety monitoring board.

Results

Between June 2016 and June 2021, 64 patients were randomized to the dense (27 patients, 42%) or conventional brush (37 patients, 58%). Malignancy was diagnosed

SUBMITTER: Gorris M 

PROVIDER: S-EPMC10234858 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature