Development of a bespoke phantom to optimize molecular PET imaging of pituitary tumors.

ABSTRACT:

Background

Image optimization is a key step in clinical nuclear medicine, and phantoms play an essential role in this process. However, most phantoms do not accurately reflect the complexity of human anatomy, and this presents a particular challenge when imaging endocrine glands to detect small (often subcentimeter) tumors. To address this, we developed a novel phantom for optimization of positron emission tomography (PET) imaging of the human pituitary gland. Using radioactive 3D printing, phantoms were created which mimicked the distribution of ¹¹C-methionine in normal pituitary tissue and in a small tumor embedded in the gland (i.e., with no inactive boundary, thereby reproducing the in vivo situation). In addition, an anatomical phantom, replicating key surrounding s

SUBMITTER: Gillett D 

PROVIDER: S-EPMC10234958 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature