A model of porcine polymicrobial septic shock.

ABSTRACT:

Background

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades. Animal models have been widely used for the study of sepsis and septic shock, but translation into effective treatment regimes in the clinic have mostly failed. Pigs are considered as suitable research models for human diseases due to their high comparability and similarity to human anatomy, genetics, and the immune system. We here evaluated the previously reported models of septic shock in pigs and established a novel model of polymicrobial sepsis that meets the clinical criteria of septic shock in pigs.

Materials and methods

The literature search was performed using the ke

SUBMITTER: Zurek-Leffers FM 

PROVIDER: S-EPMC10235002 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature