Asymmetric rotaxanes as dual-modality supramolecular imaging agents for targeting cancer biomarkers.

ABSTRACT: Dual-modality imaging agents featuring both a radioactive complex for positron emission tomography (PET) and a fluorophore for optical fluorescence imaging (OFI) are crucial tools for reinforcing clinical diagnosis and intraoperative surgeries. We report the synthesis and characterisation of bimodal mechanically interlocked rotaxane-based imaging agents, constructed via the cucurbit[6]uril CB[6]-mediated alkyne-azide 'click' reaction. Two synthetic routes involving four- or six-component reactions are developed to access asymmetric rotaxanes. Furthermore, by using this rapid and versatile approach, a peptide-based rotaxane targeted toward the clinical prostate cancer biomarker, prostate-specific membrane antigen (PSMA), and bearing a ⁶⁸Ga-radiometal ion complex for positron emis

SUBMITTER: d'Orchymont F 

PROVIDER: S-EPMC10235045 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature