Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR^CSTMLR mutant protein: molecular modeling and free energy approach.

ABSTRACT: EGFR (epidermal growth factor receptor), a surface protein on the cell, belongs to the tyrosine kinase family, responsible for cell growth and proliferation. Overexpression or mutation in the EGFR gene leads to various types of cancer, i.e., non-small cell lung cancer, breast, and pancreatic cancer. Bioactive molecules identified in this genre were also an essential source of encouragement for researchers who accomplished the design and synthesis of novel compounds with anticancer properties. World Health Organization (WHO) report states that antibiotic resistance is one of the most severe risks to global well-being, food safety, and development. The world needs to take steps to lessen this danger, such as developing new antibiotics and regulating their use. In this study, 6524 compounds d

SUBMITTER: Saini R 

PROVIDER: S-EPMC10235079 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature