Ontology highlight
ABSTRACT:
SUBMITTER: Bravo-Iniguez CE
PROVIDER: S-EPMC10235098 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Bravo-Iñiguez Carlos E CE Fritz Jason R JR Shukla Shilpa S Sarangi Susmita S Thompson Dane A DA Amin Seema G SG Tsaava Tea T Chaudhry Saher S Valentino Sara P SP Hoffman Hannah B HB Imossi Catherine W CW Addorisio Meghan E ME Valdes-Ferrer Sergio I SI Chavan Sangeeta S SS Blanc Lionel L Czura Christopher J CJ Tracey Kevin J KJ Huston Jared M JM
Nature communications 20230601 1
Deficiency of coagulation factor VIII in hemophilia A disrupts clotting and prolongs bleeding. While the current mainstay of therapy is infusion of factor VIII concentrates, inhibitor antibodies often render these ineffective. Because preclinical evidence shows electrical vagus nerve stimulation accelerates clotting to reduce hemorrhage without precipitating systemic thrombosis, we reasoned it might reduce bleeding in hemophilia A. Using two different male murine hemorrhage and thrombosis models ...[more]