Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice.

ABSTRACT: The increased incidence of obesity in the global population has increased the risk of several chronic inflammation-related diseases, including non-alcoholic steatohepatitis (NASH)-hepatocellular carcinoma (HCC). The progression from NASH to HCC involves a virus-independent liver carcinogenic mechanism; however, we currently lack effective treatment and prevention strategies. Several reports have suggested that fecal volatile organic compounds (VOCs) are strongly associated with NASH-HCC; therefore, we explored the biomarkers involved in its pathogenesis and progression. Fecal samples collected from control and NASH-HCC model STAM mice were subjected to headspace autosampler gas chromatography-electron ionization-mass spectrometry. Non-target profiling analysis identified diacetyl (2,3-buta

SUBMITTER: Kato M 

PROVIDER: S-EPMC10235110 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature