High-pressure studies in the supercooled and glassy state of the strongly associated active pharmaceutical ingredient-ticagrelor.

ABSTRACT: In this paper, the molecular dynamics at different thermodynamic conditions of hydrogen-bonded (H-bonded) active pharmaceutical ingredient-ticagrelor (TICA) have been investigated. Extensive high-pressure (HP) dielectric studies revealed surprising high sensitivity of the structural (α)-relaxation to compression. They also showed that unexpectedly the shape of the α-peak remains invariable at various temperature (T) and pressure (p) conditions at constant α-relaxation time. Further infrared measurements on the ordinary and pressure densified glasses of the examined compound indicated that the hydrogen-bonding pattern in TICA is unchanged by the applied experimental conditions. Such behavior was in contrast to that observed recently for ritonavir (where the organization of hydrogen bonds va

SUBMITTER: Jesionek P 

PROVIDER: S-EPMC10235114 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature