Body Mass Index and Cognition: Associations Across 
Mid- to Late Life and Gender Differences.

ABSTRACT:

Background

Higher mid-life body mass index (BMI) is associated with lower late-life cognition. Associations between later-life BMI and cognition are less consistent; evidence suggests reverse causation may play a role. We aimed to characterize associations between BMI and cognition across a wide age range during mid- to late life (55-85 years) and examine whether associations vary by gender.

Methods

We used data from the Health and Retirement Study (HRS) (N = 39,153) to examine the association between BMI and 3 cognitive outcomes: cognitive level, cognitive decline, and cognitive impairment. We used a series of linear regression, mixed effects regression, and logistic regression models, adjusting for potential confounders.

Results

Higher BMI before age 65 (midlife) wa

SUBMITTER: Crane BM 

PROVIDER: S-EPMC10235201 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature