Staphylococcus aureus δ-toxin present on skin promotes the development of food allergy in a murine model.

ABSTRACT:

Background

Patients with food allergy often suffer from atopic dermatitis, in which Staphylococcus aureus colonization is frequently observed. Staphylococcus aureus δ-toxin activates mast cells and promotes T helper 2 type skin inflammation in the tape-stripped murine skin. However, the physiological effects of δ-toxin present on the steady-state skin remain unknown. We aimed to investigate whether δ-toxin present on the steady-state skin impacts the development of food allergy.

Material and methods

The non-tape-stripped skins of wild-type, Kit^W-sh/W-sh, or ST2-deficient mice were treated with ovalbumin (OVA) with or without δ-toxin before intragastric administration of OVA. The frequency of diarrhea, numbers of jejunum or skin mast cells, and

SUBMITTER: Yamada H 

PROVIDER: S-EPMC10235538 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature