In-depth mining of single-cell transcriptome reveals the key immune-regulated loops in age-related macular degeneration.

ABSTRACT:

Introduction

Age-related macular degeneration (AMD), an ever-increasing ocular disease, has become one of the leading causes of irreversible blindness. Recent advances in single-cell genomics are improving our understanding of the molecular mechanisms of AMD. However, the pathophysiology of this multifactorial disease is complicated and still an ongoing challenge. To better understand disease pathogenesis and identify effective targets, we conducted an in-depth analysis of the single-cell transcriptome of AMD.

Methods

The cell expression specificity of the gene (CESG) was selected as an index to identify the novel cell markers. A computational framework was designed to explore the cell-specific TF regulatory loops, containing the interaction of gene pattern signatures, trans

SUBMITTER: Wang W 

PROVIDER: S-EPMC10235539 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature