Remote effects of temporal lobe epilepsy surgery: Long-term morphological changes after surgical resection.

ABSTRACT:

Objective

Epilepsy surgery is an effective treatment for drug-resistant patients. However, how different surgical approaches affect long-term brain structure remains poorly characterized. Here, we present a semiautomated method for quantifying structural changes after epilepsy surgery and compare the remote structural effects of two approaches, anterior temporal lobectomy (ATL), and selective amygdalohippocampectomy (SAH).

Methods

We studied 36 temporal lobe epilepsy patients who underwent resective surgery (ATL = 22, SAH = 14). All patients received same-scanner MR imaging preoperatively and postoperatively (mean 2 years). To analyze postoperative structural changes, we segmented the resection zone and modified the Advanced Normalization Tools (ANTs) longitudinal cortical p

SUBMITTER: Arnold TC 

PROVIDER: S-EPMC10235552 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature