The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study.

ABSTRACT:

Objective

We aimed to explore the underlying pathomechanisms of the comorbidity between three common systemic autoimmune disorders (SADs) [i.e., insulin-dependent diabetes mellitus (IDDM), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA)] and temporal lobe epilepsy (TLE), using bioinformatics tools. We hypothesized that there are shared genetic variations among these four conditions.

Methods

Different databases (DisGeNET, Harmonizome, and Enrichr) were searched to find TLE-associated genes with variants; their single nucleotide polymorphisms (SNPs) were gathered from the literature. We also did a separate literature search using PubMed with the following keywords for original articles: "TLE" or "Temporal lobe epilepsy" AND "genetic variation," "single nucleo

SUBMITTER: Malekpour M 

PROVIDER: S-EPMC10235559 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature