Potential role of FKBP5 single-nucleotide polymorphisms in functional seizures.

ABSTRACT:

Objective

We investigated the associations between FKBP5 single-nucleotide polymorphisms (SNPs) and functional seizures (FS).

Methods

Seventy patients with FS, 140 with major depressive disorder (MDD), and 140 healthy controls were studied. Their DNAs were analyzed for the rs1360780 in the 3' region and rs9470080 in the 5' region of the FKBP5. Childhood trauma questionnaire and hospital anxiety and depression scale were used.

Results

Patients with FS and those with MDD had less GG and more AA genotypes in both rs9470080 and rs1360780 SNPs compared with those in healthy controls. Similar results were observed for allelic frequencies. There were no significant differences between FS and MDD groups in terms of genotype and allelic frequencies for both SNPs. The results o

SUBMITTER: Asadi-Pooya AA 

PROVIDER: S-EPMC10235573 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature