Polygenic risk, familial liability and stress reactivity in psychosis: an experience sampling study.

ABSTRACT:

Background

There is evidence for a polygenic contribution to psychosis. One targetable mechanism through which polygenic variation may impact on individuals and interact with the social environment is stress sensitization, characterized by elevated reactivity to minor stressors in daily life. The current study aimed to investigate whether stress reactivity is modified by polygenic risk score for schizophrenia (PRS) in cases with enduring non-affective psychotic disorder, first-degree relatives of cases, and controls.

Methods

We used the experience sampling method to assess minor stressors, negative affect, positive affect and psychotic experiences in 96 cases, 79 first-degree relatives, i.e. siblings, and 73 controls at wave 3 of the Dutch Genetic Risk and Outcome of Psychos

SUBMITTER: Schick A 

PROVIDER: S-EPMC10235643 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature