Fatty acid amides as potential circulating biomarkers for sarcopenia.

ABSTRACT:

Background

Sarcopenia is characterized by a progressive decrease in skeletal muscle mass and function with age. Given that sarcopenia is associated with various metabolic disorders, effective metabolic biomarkers for its early detection are required. We aimed to investigate the metabolic biomarkers related to sarcopenia in elderly men and perform experimental studies using metabolomics.

Methods

Plasma metabolites from 142 elderly men, comprising a sarcopenia group and an age-matched control group, were measured using global metabolome profiling. Muscle and plasma samples from an aging mouse model of sarcopenia, as well as cell media and cell lysates during myoblast differentiation, were analysed based on targeted metabolome profiling. Based on these experimental results, fat

SUBMITTER: Kim YA 

PROVIDER: S-EPMC10235865 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature