Muscle stem cells contribute to long-term tissue repletion following surgical sepsis.

ABSTRACT:

Background

Over the past decade, advances in sepsis identification and management have resulted in decreased sepsis mortality. This increase in survivorship has highlighted a new clinical obstacle: chronic critical illness (CCI), for which there are no effective treatment options. Up to half of sepsis survivors suffer from CCI, which can include multi-organ dysfunction, chronic inflammation, muscle wasting, physical and mental disabilities, and enhanced frailty. These symptoms prevent survivors from returning to regular day-to-day activities and are directly associated with poor quality of life.

Methods

Mice were subjected to cecal ligation and puncture (CLP) with daily chronic stress (DCS) as an in vivo model to study sepsis late-effects/sequelae on skeletal muscle componen

SUBMITTER: Schmitt RE 

PROVIDER: S-EPMC10235871 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature