Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women.

ABSTRACT:

Background

Impaired muscle function has been identified as a risk factor for declining cognitive function and cardiovascular health, both of which are risk factors for late-life dementia (after 80 years of age). We examined whether hand grip strength and timed-up-and-go (TUG) performance, including their change over 5 years, were associated with late-life dementia events in older women and whether any associations provided independent information to Apolipoprotein E _ℇ 4 (APOE _ℇ 4) genotype.

Methods

Grip strength and TUG were assessed in community-dwelling older women (mean ± SD; age 75.0 ± 2.6 years) at baseline (n = 1225) and 5 years (n = 1052). Incident 14.5-year late-life dementia events (dementia-related hospitalization/death) were obtained from lin

SUBMITTER: Radavelli-Bagatini S 

PROVIDER: S-EPMC10235875 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature