A novel orthotopic mouse model replicates human lung cancer cachexia.

ABSTRACT:

Introduction

Cancer cachexia, highly prevalent in lung cancer, is a debilitating syndrome characterized by involuntary loss of skeletal muscle mass and is associated with poor clinical outcome, decreased survival and negative impact on tumour therapy. Various lung tumour-bearing animal models have been used to explore underlying mechanisms of cancer cachexia. However, these models do not simulate anatomical and immunological features key to lung cancer and associated muscle wasting. Overcoming these shortcomings is essential to translate experimental findings into the clinic. We therefore evaluated whether a syngeneic, orthotopic lung cancer mouse model replicates systemic and muscle-specific alterations associated with human lung cancer cachexia.

Methods

Immune competent, 1

SUBMITTER: van de Worp WRPH 

PROVIDER: S-EPMC10235890 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature