Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism.

ABSTRACT: Contraction of skeletal muscle is triggered by a transient rise in intracellular calcium concentration leading to a structural change in the actin-containing thin filaments that allows binding of myosin motors from the thick filaments. Most myosin motors are unavailable for actin binding in resting muscle because they are folded back against the thick filament backbone. Release of the folded motors is triggered by thick filament stress, implying a positive feedback loop in the thick filaments. However, it was unclear how thin and thick filament activation mechanisms are coordinated, partly because most previous studies of the thin filament regulation were conducted at low temperatures where the thick filament mechanisms are inhibited. Here, we use probes on both troponin in the thin filame

SUBMITTER: Brunello E 

PROVIDER: S-EPMC10235942 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature