Activating P2Y1 receptors improves function in arteries with repressed autophagy.

ABSTRACT:

Aim

The importance of endothelial cell (EC) autophagy to vascular homeostasis in the context of health and disease is evolving. Earlier, we reported that intact EC autophagy is requisite to maintain shear-stress-induced nitric oxide (NO) generation via glycolysis-dependent purinergic signalling to endothelial NO synthase (eNOS). Here, we illustrate the translational and functional significance of these findings.

Methods and results

First, we assessed translational relevance using older male humans and mice that exhibit blunted EC autophagy and impaired arterial function vs. adult controls. Active hyperaemia evoked by rhythmic handgrip exercise-elevated radial artery shear-rate similarly from baseline in adult and older subjects for 60 min. Compared with baseline, indexes of

SUBMITTER: Cho JM 

PROVIDER: S-EPMC10236004 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature