Imaging features of small vessel disease in cerebral amyloid angiopathy among patients with Alzheimer's disease.

ABSTRACT:

Background and purpose

Cerebral small vessel disease biomarkers including white matter hyperintensities (WMH), lacunes, and enlarged perivascular spaces (ePVS) are under investigation to identify those specific to cerebral amyloid angiopathy (CAA). In subjects with Alzheimer's disease (AD), we assessed characteristic features and amounts of WMH, lacunes, and ePVS in four CAA categories (no, mild, moderate and severe CAA) and correlated these with Clinical Dementia Rating sum of boxes (CDRsb) score, ApoE genotype, and neuropathological changes at autopsy.

Methods

The study included patients with a clinical diagnosis of dementia due to AD and neuropathological confirmation of AD and CAA in the National Alzheimer's Coordinating Center (NACC) database. The WMH, lacunes, and ePVS

SUBMITTER: Nagaraja N 

PROVIDER: S-EPMC10236212 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature