Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study.

ABSTRACT:

Background

Compared with adults with normal glucose metabolism, those with prediabetes tend to be frail. However, it remains poorly understood whether frailty could identify adults who are most at risk of adverse outcomes related to prediabetes.

Objective

We aimed to systematically evaluate the associations between frailty, a simple health indicator, and risks of multiple adverse outcomes including incident type 2 diabetes mellitus (T2DM), diabetes-related microvascular disease, cardiovascular disease (CVD), chronic kidney disease (CKD), eye disease, dementia, depression, and all-cause mortality in late life among middle-aged adults with prediabetes.

Methods

We evaluated 38,950 adults aged 40 years to 64 years with prediabetes using the baseline survey from the UK Bio

SUBMITTER: Cao X 

PROVIDER: S-EPMC10236284 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature