Cell atlas of CCl ₄-induced progressive liver fibrosis reveals stage-specific responses.

ABSTRACT: Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis, a major cause of morbidity and mortality worldwide. However, there are currently no effective anti-fibrotic therapies available, especially for late-stage patients, which is partly attributed to the major knowledge gap regarding liver cell heterogeneity and cell-specific responses in different fibrosis stages. To reveal the multicellular networks regulating mammalian liver fibrosis from mild to severe phenotypes, we generated a single-nucleus transcriptomic atlas encompassing 49 919 nuclei corresponding to all main liver cell types at different stages of murine carbon tetrachloride (CCl ₄)-induced progressive liver fibrosis. Integrative analysis distinguished the sequential responses to injury of

SUBMITTER: Guo PC 

PROVIDER: S-EPMC10236302 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature