Control of enhancer and promoter activation in the type I interferon response by the histone demethylase Kdm4d/JMJD2d.

ABSTRACT:

Introduction

Transcriptional activation depends on the interplay of chromatin modifiers to establish a permissive epigenetic landscape. While histone 3 lysine 9 (H3K9) methylation has long been associated with gene repression, there is limited evidence to support a role for H3K9 demethylases in gene activation.

Methods

We leveraged knockdown and overexpression of JMJD2d / Kdm4d in mouse embryonic fibroblasts, coupled with extensive epigenomic analysesm to decipher the role of histone 3 lysine 9 demethylases in the innate immune response.

Results

Here we describe the H3K9 demethylase Kdm4d/JMJD2d as a positive regulator of type I interferon responses. In mouse embryonic fibroblasts (MEFs), depletion of JMJD2d attenuates the transcriptional response, conferring increase

SUBMITTER: Chandwani R 

PROVIDER: S-EPMC10236313 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature