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Native Amides as Enabling Vehicles for Forging sp³-sp³ Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking.

ABSTRACT: Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp³-sp³ architectures at remote, yet previously unfunctionalized, methylene sp³ C-H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, including challenging substrate combinations. Site-selectivity can be dictated by a judicious choice of the ligand, thus offering an opportunity to enable sp³-sp³ bond formations that are otherwise inaccessible in conventional chain-walking events.

SUBMITTER: Rodrigalvarez J

PROVIDER: S-EPMC10236437 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Native Amides as Enabling Vehicles for Forging sp3-sp3 Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking.

Rodrigalvarez Jesus J Wang Hao H Martin Ruben R

Journal of the American Chemical Society 20230208 7

Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp3-sp3 architectures at remote, yet previously unfunctionalized, methylene sp3 C-H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, including challenging substrate combinations. Site-selectivity can be dictated by a judicious choice of the ligand, thus offering an opportunity to enable sp3 ...[more]

PMID: 36753384

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