Native Amides as Enabling Vehicles for Forging sp³-sp³ Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking.

ABSTRACT: Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp³-sp³ architectures at remote, yet previously unfunctionalized, methylene sp³ C-H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, including challenging substrate combinations. Site-selectivity can be dictated by a judicious choice of the ligand, thus offering an opportunity to enable sp³-sp³ bond formations that are otherwise inaccessible in conventional chain-walking events.

SUBMITTER: Rodrigalvarez J 

PROVIDER: S-EPMC10236437 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature