DNA Methylation Changes in Autologous Hematopoietic Stem Cell Transplant Patients.

ABSTRACT:

Background

Blood cancers may be potentially cured with hematopoietic stem cell transplantation (HCT); however, standard pre-assessments for transplant eligibility do not capture all contributing factors for transplant outcomes. Epigenetic biomarkers predict outcomes in various diseases. This pilot study aims to explore epigenetic changes (epigenetic age and differentially methylated genes) in patients before and after autologous HCT, that can serve as potential biomarkers to better predict HCT outcomes.

Methods

This study used a prospective longitudinal study design to compare genome wide DNA methylation changes in 36 autologous HCT eligible patients recruited from the Cellular Immunotherapies and Transplant clinic at a designated National Cancer Center.

Results

Genom

SUBMITTER: Mohanraj L 

PROVIDER: S-EPMC10236442 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature