Photoacoustic imaging provides an in vivo assessment of the preeclamptic placenta remodeling and function in response to therapy.

ABSTRACT:

Introduction

There is a lack of effective therapeutic interventions for preeclampsia. A central factor in the etiology of the disease is the development of placental hypoxia due to abnormal vascular remodeling. However, methods to assess the impact of potential therapies on placental growth and remodeling are currently lacking. Here, we develop and validate ultrasound-guided photoacoustic imaging methods to monitor the placental response to therapeutic intervention. Establishing non-invasive tools to image placental function opens up previously unachievable understandings of placental therapeutic response.

Methods

Studies were performed in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia. Preclinical research has identified tempol, a superoxide dismuta

SUBMITTER: Lawrence DJ 

PROVIDER: S-EPMC10236486 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature