Network Effects of Brain Lesions Causing Central Poststroke Pain.

ABSTRACT:

Objective

This study was undertaken to test whether lesions causing central poststroke pain (CPSP) are associated with a specific connectivity profile, whether these connections are associated with metabolic changes, and whether this network aligns with neuromodulation targets for pain.

Methods

Two independent lesion datasets were utilized: (1) subcortical lesions from published case reports and (2) thalamic lesions with metabolic imaging using 18F- fluorodeoxyglucose positron emission tomography-computed tomography. Functional connectivity between each lesion location and the rest of the brain was assessed using a normative connectome (n = 1,000), and connections specific to CPSP were identified. Metabolic changes specific to CPSP were also identified and related to differe

SUBMITTER: Kim NY 

PROVIDER: S-EPMC10236498 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature